O'Halloran Lab >

Publications

O'HALLORAN GROUP PUBLICATIONS

2023

  • Chen Y, Chen S, Ok K, Duncan FE, O’Halloran TV, Woodruff TK. Zinc dynamics regulate early ovarian follicle development. JBC. 2023, 299(1):102731 

2022

  • Sue AC, Wignall SM, Woodruff TK, O’Halloran TV. “Zinc transporters ZIPT-2.4 and ZIPT-15 are required for normal C. elegans fecundity”. J Assist Reprod Genet. 2022.
  • Mendoza AD, Sue A, Antipova O, Vogt S, Woodruff TK, Wignall SM, O’Halloran TV. “Dynamic Zinc Fluxes Regulate Meiotic Progression in Caenorhabditis elegans”. Biol Reprod. 2022.
  • Zee DZ, MacRenaris KM, O’Halloran TV. “Quantitative Imaging Approaches to Understanding Biological Processing of Metal Ions”. Curr Opin Chem Biol. 2022.

2021

  • Miodragović Ð, Qiang W, Waxali ZS, Vitnik Ž, Vitnik, V, Yang Y, Farrell A, Martin M, Ren J, O’Halloran TV. “Iodide Analogs of Arsenoplatins—Potential Drug Candidates for Triple Negative Breast Cancers”. Molecules 2021;26: 5421.
  • Hu Q, Antipova OA, O’Halloran TV, Wolfner MF. “X-ray fluorescence microscopy scanning of Drosophila oocytes and eggs” Star Protoc. 2021;2:100247.
  • Fang C, Philips SJ, Wu X, Chen K, Shi J, Shen L, Xu J, Feng Y, O’Halloran TV, Zhang Y. “CueR Activates Transcription Through a DNA Distortion Mechanism” Nat Chem Biol. 2021;17:57–64.
  • Seeler JF, Sharma A, Zaluzec NJ, Bleher R, Lai B, Schultz EG, Hoffman BM, LaBonne C, Woodruff TK, and O’Halloran TV.  “Metal Ion Fluxes Controlling Amphibian Fertilization” Nat Chem. 2021;1–9.

2020

  • Fang C, Li L,  Zhao Y, Wu X, Philips SJ, You L, Zhong M, Shi X, O’Halloran TV, Li Q, Zhang Y. “The Bacterial Multidrug Resistance Regulator BmrR Distorts Promoter DNA to Activate Transcription” Nat Commun. 2020;11:6284.
  • Lee HC, Edmonds ME, Duncan FE, O’Halloran TV, Woodruff TK. “Zinc Exocytosis is Sensitive to Myosin Light Chain Kinase Inhibition in Mouse and Human Eggs” Mol Hum Reprod. 2020;26:228–239.
  • Hu Q, Duncan FE, Nowakowski AB, Antipova OA, Woodruff TK, O’Halloran TV, Wolfner MF. “Zinc Dynamics during Drosophila Oocyte Maturation and Egg Activation” iScience. 2020;23:101275.

2019

  • Miodragović Đ, Merlino A, Swindell EP, Bogachkov A, Ahn RW, Abuhadba S, Ferraro G, Marzo T, Mazar AP, Messori L, O’Halloran TV. “Arsenoplatin-1 is a Dual Pharmacophore Anti-Cancer Agent” J Am Chem Soc. 2019 Apr 3. doi: 10.1021/jacs.8b13681. [Epub ahead of print]
  • Que EL, Duncan FE, Lee HC, Hornick JE, Vogt S, Fissore RA, O’Halloran TV, Woodruff TK. “Bovine eggs release zinc in response to parthenogenetic and sperm-induced egg activation” Theriogenology. 2019  Mar 15;127:41-48. doi: 10.1016/j.theriogenology.2018.12.031. Epub 2018 Dec 24. [Epub ahead of print] PMID: 30639695
  • Johnson SE, Ugolkov A, Haney CR, Bondarenko G, Li L, Waters EA, Bergan R, Tran A, O’Halloran TV, Mazar A, Zhao M. “Whole-body Imaging of Cell Death Provides a Systemic, Minimally Invasive, Dynamic and Near-real Time Indicator for Chemotherapeutics.” Clin Cancer Res 2019 Feb 15;25(4):1331-1342. PMID: 30420445
  • Zaluzec NJ, Seeler J, Bleher R, O’Halloran TV. “Challenges in Biological X-ray Microanalysis in the AEM.” Microsc Microanal. 2019;25:1076–1077.
  • Stephens AD, Liu PZ, Kandula V, Chen H, Almassalha LM, Herman C, Backman V, O’Halloran TV, Adam SA, Goldman RD, Banigan EJ, Marko JF. “Physicochemical Mechanotransduction Alters Nuclear Shape and Mechanics via Heterochromatin Formation.” Mol Biol Cell. 2019;30:2320–2330. PMCID: PMC6743459.
  • Garwin SA, Kelley MS, Sue AC, Que EL, Schatz GC, Woodruff TK, O’Halloran TV. “Interrogating Intracellular Zinc Chemistry with a Long Stokes Shift Zinc Probe ZincBY-4.” J Am Chem Soc. 2019;141:16696–16705. PMCID: PMC6812604.
  • Miodragović Ð, Swindell EP, Sattar Waxali Z, Bogachkov A, O’Halloran TV. “Beyond Cisplatin: Combination Therapy with Arsenic Trioxide.” Inorg Chim Acta. 2019;496:119030.

2018

  • Ugolkov AV, Matsangou M, Taxter TJ, O’Halloran TV, Cryns VL, Giles FJ, Mazar AP “Aberrant expression of Glycogen Synthase Kinase -3b in human breast and head and neck cancer” Oncology Letters. 2018 Nov;16(5):6437-6444. doi: 10.3892/ol.2018.9483. Epub 2018 Sep 21. PMID: 30405781
  • Ugolkov AV, Bondarenko GI, Dubrovskyi O, Berbegall AP, Navarro S, Noguera R, O’Halloran TV, Hendrix MJ, Giles FJ, Mazar AP. “9-ING-41, a small-molecule glycogen synthase kinase-3 inhibitor, is active in neuroblastoma” Anticancer Drugs. 2018 May 25. doi: 10.1097/CAD.0000000000000652. [Epub ahead of print] PMID: 29846250
  • Velasco E, Wang S, Sanet M, Fernández-Vázquez J, Jové D, Glaría E, Valledor AF, O’Halloran TV, Balsalobre C. “A new role for Zinc limitation in bacterial pathogenicity: modulation of α-hemolysin from uropathogenic Escherichia coli” Sci Rep. 2018 Apr 25;8(1):6535. doi: 10.1038/s41598-018-24964-1

2017

  • Almassalha LM, Bauer GM, Wu, W, Cherkezyan L, Zhang D, AKendra A, Gladstein S, Chandler JE, VanDerway D, Seagle B-LL, Ugolkov A, D Billadeau DD, O’Halloran TV, Mazar AP, Roy HK, Szleifer I, Shahabi S, Backman V “Macrogenomic engineering via modulation of the scaling of chromatin packing density” Nature Biomedical Engineering  2017 Nov. 1:902-913. doi:10.1038/s41551-017-0153-2
  • Ugolkov A, Qiang W, Bondarenko G, Procissi D, Gaisina I, Kozokowski A, Procissi, D, Bondarenko G, Qiang W, Chandlker, JP, James CA, O’Halloran TV, Mazar A, Raizer, J “Combination treatment with the GSK-3 inhibitor 9-ING-41 and CCNU cures orthotopic chemoresistant glioblastoma in patient-derived xenograft models.”  Translational Oncology 2017 Aug;10(4):669-678. doi: 10.1016/j.tranon.2017.06.003. Epub 2017 Jun 30.
  • Que EL, Duncan FE, Bayer AR, Philips SJ, Roth EW, Bleher R, Gleber SC, Vogt S, Woodruff TK, O’Halloran TV “Zinc sparks induce physiochemical changes in the egg zona pellucida that prevent polyspermy”. Integr Biol (Camb). 2017 Jan 19. doi: 10.1039/c6ib00212a. [Epub ahead of print] PMID: 28102396.
  • Walz, A, Ugolkov, A, Chandra, S, Kozikowski, A, Carneiro, B, O’Halloran, T, Giles, F, Billadeau, Mazar, M “Molecular Pathways: Revisiting Glycogen Synthase Kinase-3 as a Target for the Treatment of Cancer” Clinical Cancer Research, 2017 Jan 4 pii: clincanres.2240.2016. doi: 10.1158/1078-0432.CCR-15-2240. [Epub ahead of print] PMID: 28053024.

2016

  • Mendoza AD, Woodruff TK, Wignall, O’Halloran TV. “Zinc Availability During Germline Development Impacts Embryo Viability in Caenorhabditis elegans” Comparative Biochemistry and Physiology Part C: Toxicology and Pharmacology (2016) Sep 21. pii:S1532-0456 (16) 301115-6. doi: 10.1016/j.cbpc.2016.09.007. [Epub ahead of print] PMID:27664515.
  • Ugolkov, A, Gaisina I, Zhang, J-S, Billadeau,D, White, K, Kozikowski, A, Jain, S, Cristofanilli, M, Giles, F, O’Halloran, T, Cryns, V, Mazar, A. “GSK-3 inhibition overcomes chemoresistance in human breast cancer” Cancer Letters (2016) Oct 1;380(2):384-92. doi: 10.1016/j.canlet.2016.07.006. Epub 2016 Jul 14. PMID: 27424289.
  • Upreti M, Jyoti A, Johnson SE, Swindell EP, Napier D, Sethi P, Chan R, Feddock JM, Weiss HL, O’Halloran TV, Evers BM. “Radiation-enhanced therapeutic targeting of galectin-1 enriched malignant stroma in triple negative breast cancer.” Oncotarget 2016 May 19. doi: 10.18632/oncotarget.9490. [Epub ahead of print] PMID: 27223428
  • Duncan FE, Que EL, Zhang N, Feinberg EC, O’Halloran TV, Woodruff TK. “The zinc spark is an inorganic signature of human egg activation” Scientific Reports. 2016 Apr 26;6:24737. doi: 10.1038/srep24737
  • Mazar AP, Ugolkov A, Henkin J, Ahn RW and O’Halloran TV, “Chapter 7: Invasion and metastasis” in Oxford Textbook of Oncology, 3rd Edition, edited by David J. Kerr, Daniel G. Haller, Cornelis J.H. van de Velde, Michael Baumann, Nagahiro Saijo, Oxford, UK:Oxford University Press, pp. 61-71, 2016
  • Zhang N, Duncan FE, Que EL, O’Halloran TV, Woodruff TK. “The fertilization-induced zinc spark is a novel biomarker of mouse embryo quality and early development” Scientific Reports. 2016 March 18;6:22772. doi: 10.1038/srep22772
  • Staehlin BM, Gibbons, JG, Rokas, A, O’Halloran TV, Slot J. “Evolution of a Heavy Metal Homeostasis/Resistance Island Reflects Increasing Copper Stress in Enterobacteria” Genome Biology and Evolution (2016) Feb 17;8(3):811-26. doi: 10.1093/gbe/evw031

2015

  • Bondarenko G, Ugolkov A, Rohan S, Kulesza P, Dubrovskyi O, Gursel D, Mathews J, O’Halloran TV, Wei JJ, Mazar AP. Patient-Derived Tumor Xenografts Are Susceptible to Formation of Human Lymphocytic Tumors. Neoplasia. 2015 Sep;17(9):735-41. doi: 10.1016/j.neo.2015.09.004. PMID: 26476081
  • Philips SJ, Canalizo-Hernandez M, Yildirim I, Schatz GC, Mondragón A, O’Halloran TV. Allosteric transcriptional regulation via changes in the overall topology of the core promoter. Science. 2015 Aug 21;349(6250):877-81. doi: 10.1126/science.aaa9809. PMID: 26293965
  • Sethi P, Jyoti A, Swindell EP, Chan R, Langner UW, Feddock JM, Nagarajan R, O’Halloran TV, Upreti M. 3D Tumor tissue analogs and their orthotopic implants for understanding tumor-targeting of microenvironment-responsive nanosized chemotherapy and radiation. Nanomedicine. 2015 Aug 14. pii: S1549-9634(15)00156-2. doi: 10.1016/j.nano.2015.07.013. [Epub ahead of print] PMID: 26282381 PMCID: PMC4548830
  • Kong BY, Duncan FE, Que EL, Xu Y, Vogt S, O’Halloran TV, Woodruff TK. The inorganic anatomy of the mammalian preimplantation embryo and the requirement of zinc during the first mitotic divisions. Developmental Dynamics. 2015 Aug;244(8):935-47. doi: 10.1002/dvdy.24285. Epub 2015 Jul 16. PMID: 25903945
  • Que EL, Bleher R, Duncan FE, Kong BY, Gleber SC, Vogt S, Chen S, Garwin SA, Bayer AR, Dravid VP, Woodruff TK, O’Halloran TV. Quantitative mapping of zinc fluxes in the mammalian egg reveals the origin of fertilization-induced zinc sparks. Nature Chemistry. 2015;7(2):130-9. doi: 10.1038/nchem.2133. PubMed PMID: 25615666; PubMed Central PMCID: PMC4315321. PDF
  • Beauchamp EM, Kosciuczuk EM, Serrano R, Nanavati D, Swindell EP, Viollet B, O’Halloran TV, Altman JK, Platanias LC. Direct binding of arsenic trioxide to AMPK and generation of inhibitory effects on acute myeloid leukemia precursors. Molecular Cancer Therapeutics. 2015;14(1):202-12. doi: 10.1158/1535-7163.MCT-14-0665-T. PubMed PMID: 25344585; PubMed Central PMCID: PMC4297272. PDF

2014

  • Gilston BA, Wang S, Marcus MD, Canalizo-Hernandez MA, Swindell EP, Xue Y,Mondragon A, O’Halloran TV. Structural and mechanistic basis of zinc regulation across the E. coli Zur regulon. PLoS Biology. 2014;12(11):e1001987. doi: 10.1371/journal.pbio.1001987. PubMed PMID: 25369000; PubMed Central PMCID: PMC4219657. PDF
  • Kong BY, Duncan FE, Que EL, Kim AM, O’Halloran TV, Woodruff TK. Maternally-derived zinc transporters ZIP6 and ZIP10 drive the mammalian oocyte-to-egg transition. Molecular Human Reproduction. 2014;20(11):1077-89. doi: 10.1093/molehr/gau066. PubMed PMID: 25143461; PubMed Central PMCID: PMC4209882.
  • Xu X; Cai Y; Wei Y; Donate F; Juarez J; Parry G; Chen L; Ahn RW; Ugolkov A; Dubrovskyi O; O’Halloran TV, Huang M; Mazar AP. “Identification of a New Epitope in uPAR as a Target for the Cancer Thereapeutic Monoclonal Antibody ATN-658, a Structural Homolog of the uPAR Binding Integrin CD11b (αM).”  PLoS One, 2014 Jan 21;9(1):e85349. PMCID: PMC3897428.
  • Hong BJ; Swindell, EP; MacRenaris, KW; Hankins, PL; Chipre, AJ; Mastarone, DJ; Ahn, RW; Meade, TJ; O’Halloran, TV; Nguyen, ST. “pH-Responsive Theranostic Polymer-Caged Nanobins (PCNs):  Enhanced Cytotoxicity and T1 MRI Contrast by Her2-Targeting.” Part. Part. Syst. Charact., 30, 770-774, 2013. PMCID: PMC3874022.
  • Hong YP, Gleber SC, O’Halloran TV, Que EL, Bleher R, Vogt S, Woodruff TK, Jacobsen C. “Alignment of low-dose x-ray fluorescence tomography images using differential phase contrast.” J. Synch. Radiat.,2014 Jan 1;21(Pt 1):229-34. PMCID: PMC3874022  PDF

2013

  • Ward JD, Marvin RG, O’Halloran TV, Jacobsen C, Vogt S.  “Rapid and Accurate Analysis of an X-Ray Fluorescence Microscopy Data Set through Gaussian Mixture-Based Soft Clustering Methods.” Microsc. Microanal., 2013 Oct;19(5):1281-9. doi: 10.1017/S1431927613012737. Epub 2013 Aug 7. PMCID: PMC3837627.
  • Zhang Y, Kenny HA, Swindell EP, Mitra AK, Hankins PL, Ahn RW, Gwin K, Mazar AP, O’Halloran TV, Lengyel E.  “Urokinase Plasminogen Activator System Targeted Delivery of Nanobis as a Novel Ovarian Cancer Therapeutics.” Mol. Cancer Ther., 2013 Dec;12(12):2628-39. PMCID: PMC3885360.
  • O’Halloran TV, Kebede M, Philips SJ, Attie AD. “Zinc, insulin, and the liver: a ménage à trois.” J. Clin. Invest., 2013 Oct 1;123(10):4136-9. Epub 2013 Sep 24.  PMCID: PMC3784553.
  • Gilston BA and O’Halloran TV “Mechanisms Controlling the Cellular Metal Economy”, in Metal in Cells, edited by Valeria Culotta and Robert S. Scott. Chichester, UK: John Wiley & Sons, Ltd, pp.3-14. 2013.
  • Swindell EP, Hankins PL, Chen H, Miodragovic DU, O’Halloran TV. “Anticancer Activity of Small-Molecule and Nanoparticulate Arsenic (III) Complexes.”  Inorg. Chem.,2013 Nov 4;52(21):12292-304. PMCID: PMC3893798.
  • Miodragovic DU, Quentzel JA, Kurutz JW, Stern CL, Ahn RW, Kandela I, Mazar AP, O’Halloran TV.  “Robust Structure and Reactivity of Aqueous Arsenous Acid-Platinum (II) Anticancer Complexes.” Angew. Chem. Int. Ed. Engl., 2013. 52;1-5.DOI: 10.1002/anie.201303251.  PMCID: PMC3932145.
  • Physical Sciences – Oncology Centers Network, Agus DB, Alexander JF, Arap W, Ashili S, Aslan JE, Austin RH, Backman V, Bethel KJ, Bonneau R, Chen WC, Chen-Tanyolac C, Choi NC, Curley SA, Dallas M, Damania D, Davies PC, Decuzzi P, Dickinson L, Estevez-Salmeron L, Estrella V, Ferrari M, Fischbach C, Foo J, Fraley SI, Frantz C, Fuhrmann A, Gascard P, Gatenby RA, Geng Y, Gerecht S, Gillies RJ, Godin B, Grady WM, Greenfield A, Hemphill C, Hempstead BL, Hielscher A, Hillis WD, Holland EC, Ibrahim-Hashim A, Jacks T, Johnson RH, Joo A, Katz JE, Kelbauskas L, Kesselman C, King MR, Konstantopoulos K, Kraning-Rush CM, Kuhn P, Kung K, Kwee B, Lakins JN, Lambert G, Liao D, Licht JD, Liphardt JT, Liu L, Lloyd MC, Lyubimova A, Mallick P, Marko J, McCarty OJ, Meldrum DR, Michor F, Mumenthaler SM, Nandakumar V, O’Halloran TV, Oh S, Pasqualini R, Paszek MJ, Philips KG, Poultney CS, Rana K, Reinhart-King CA, Ros R, Semenza GL, Senechal P, Shuler ML, Srinivasan S, Staunton JR, Stypula Y, Subramanian H, Tlsty TD, Tormoen GW, Tseng Y, van Oudenaarden A, Verbridge SS, Wan JC, Weaver VM, Widom J, Will C, Wirtz D, Wojtkowiak J, Wu PH. “A Physical Sciences Network Characterization of Non-tumorigenic and Metastatic Cells.” Scientific Reports., 2013;3:1449 doi 10.1038/srep01449 PMCID: PMC23618955.
  • O’Halloran TV, Ahn RW, Hankins P, Swindell EP, Mazar AP. “The many spaces of uPAR: Delivery of Theranostic Agents and Nanobins to Multiple Tumor Compartments through a Single Target” Theranostics, 2013 3(7): 496-506.  PMCID: PMC3706693
  • Ahn RW, Barrett SL, Raja MR, Jozefik JK, Spaho L, Chen H, Bally MB, Mazar AP, Avram MJ, Winter JN, Gordon LI, Shea LD, O’Halloran TV, Woodruff TK. Nano-Encapsulation of Arsenic Trioxide Enhances Efficacy Against Murine Lymphoma Model while Minimizing Its Impact on Ovarian Reserve In Vitro and In Vivo. PLoS ONE. 2013;8(3):e58491.PMCID: PMC3603968       PDF
  • Raja MR, Waterman SR, Qui J, Bleher R, Williamson PR, O’Halloran TV. “A copper hyperaccumulation phenotype correlates with pathogenesis in Cryptococcus neoformans,” Metallomics. 2013 Mar 19. [Epub ahead of print] NIHMS457671        PDF

2012

  • El Muayed M, Raja MR, Zhang X, Macrenaris KW, Bhatt S, Chen X, Urbanek M, O’Halloan TV, Lowe WL Jr.  “Accumulation of cadmium in insulin-producing B cells.” Islets 2012 Nov 1;4(6):405-16. Doi: 10.4161/isl23101. Epub 2012 Nov 1.  PMID: 23466887  PDF
  • Wu JS, Kim AM, Bleher R, Myers BD, Marvin RG, Inada H, Nakamura K, Zhang XF, Roth E, Li SY, Woodruff TK, O’Halloran TV, Dravid VP. “Imaging and elemental mapping of biological specimens with a dual-EDS dedicated scanning transmission electron microscope.” Ultramicroscopy  (2013), pp. 24-31 DOI information: 10.1016/j.ultramic.2013.01.004  NIHMS: 443219    PDF
  • Krovi, S.A.; Swindell, E.P.; O’Halloran, T.V.; Nguyen, S.T., “Improved anti-proliferative effect of doxorubicin-containing polymer nanoparticles upon surface modification with cationic groups,” J. Mater. Chem., 2012, DOI: 10.1039/C2JM35420A. PMCID: PMC3598622   PDF
  • Waterman S, Park YD, Raja M, Qiu J, Hammoud D, O’Halloran TV, Williamson P.  Role of CTR4 in the virulence of Cryptococcus neoformans.  MBio. 2012 Oct 2;3(5). Pii: e00285-12. Doi.1128/mBio.00285.  PMIC: 23033470   PDF
  • Marvin RG, Wolford JL, Kidd MJ, Ward J, Que EL. Mayer ML, Penner-Hahn JE, Haldar K, O’Halloran TV.  Fluxes in “free” and total zinc are essential for progression of intraerythrocytic stages of Plasmodium falciparum.  Chem Biol. 2012 Jun 22;19(6):731-41.  PMID: 22726687.  NIHMS386750.    PDF
  • Kong BY, Bernhardt ML, Kim AM, O’Halloran TV, Woodruff TK. Zinc Maintains Prophase Arrest in Mouse Oocytes Through Regulation of the MOS-MAPK Pathway. Biol Reprod. 2012 Jul 1;87(1):11. PMCID: PMC 3406555     PDF
  • Bernhardt ML, Long BY, Kim AM, O’Halloran TB, Woodruff TK. A Zinc-Dependent Mechanism Regulates Meiotic Progression in Mammalian Oocytes.  Biol Reprod. 2012 Feb 1. [Epub ahead of print].  PMCID: PMC3338659    PDF

2011

  • Schmidt B, Mahmud G, Soh S, Kim SH, Page T, O’Halloran TV, Gryzbowski, BA, Hoffman BM. Design, Implementation, Simulation, and Visualization of a highly efficient RIM microfluidic mixer for rapid freeze-quench of biological samples. Appl Magn Reson. 2011 Feb 11;40(4):415-425.  PMCID:  PMC3237052   PDF
  • Simm C, Luan CH, Weiss E, O’Halloran TV. High-throughput screen for indentifying small molecules that target fungal zinc homeostasis.  PLoS One. 2011;6(9):e25136. Epub 2011 Sep 29 PMCID: PMC3182986    PDF
  • Mazar AP, Ahn RW, O’Halloran TV. Development of novel therapeutics targeting the urokinase plaminogen activator receptor (uPAR) and their translation toward the clinic. Curr Pharm Des. 2011;17(19):1970-8.  PDF
  • Kim AM, Bernhardt ML, Kong BY, Ahn RW, vogt S, Woodruff TK, O’Halloran TV. Zinc sparks are triggered by fertilization and facilitate cell cycle resumption in mammalian eggs.  ACS Chem Biol. 2011 Jul 15;6(7):716-23 Epub 2011 Apr PDF
  • Lee S-M, Lee OS, O’Halloran TV, Schatz GC, Nguyen ST. Triggered release of pharmacophores for [Ni(HAsO3)]-loaded polymer-caged nanobin enhances pro-apoptotic activity: a combine experimental and theoretical study. ACS Nano. 2011 May 24;5(5):3961-9. Epub 2011 May 9. PDF

2010

  • Lee S-M, Song Y, Hong BJ, Macrenaris KW, Mastarone DJ, O’Halloran TV, Meade TJ, Nguyen ST. Modular polymer-caged nanobins as a theranostic platform with enhanced magnetic resonance relaxivity and pH-responsive drug release. Angew. Chem. Int. Ed. 2010 Nov 16 [Epub ahead of print]. PDF
  • Lee S-M, O’Halloran TV, Nguyen ST. Polymer-caged nanobins for synergistic cisplatin-doxorubicin combination chemotherapy. J Am Chem Soc. 2010 Nov 15 [Epub ahead of print]. PDF
  • Bernhardt ML, Kim AM, O’Halloran TV, Woodruff TK. Zinc requirement during meiosis I-meiosis II transition in mouse oocytes is inependent of the MOS-MAPK pathway. Biol Reprod. 2010 Nov 10. [Epub ahead of print]. PDF
  • Lee S-M, Ahn RW, Chen F, Fought AJ, O’Halloran TV, Cryns VL, Nguyen ST. Biological evaluation of pH-responsive polymer-caged nanobins for breast cancer therapy. ACS Nano.2010 Sep 28;4(9):4971-8. PDF
  • Kim AM, Vogt S, O’Halloran TV, Woodruff TK. Zinc availability regulates exit from meiosis in maturing mammalian oocytes. Nat Chem Bio. 2010 Sep;6(9):674-81. Epub 2010 Aug 8. PDF
  • Winter ND, Murphy RK, O’Halloran TV, Schatz GC. Development and modeling arsenic-trioxide-loaded thermosensitive liposomes for anticancer drug delivery. J Liposome Res. 2011 Jun;21(2):106-15.
  • El Muayed M., Billings, L.K., Raja M.R., Zhang X., Park P.J., Newman M.V., Kaufman D.B., O’Halloran T.V., Lowe W.L. Jr. Acute cytokine-mediated downregulation of the zinc transporter ZnT8 alters pancreatic {beta}-cell function. J Endocrinol. 2010 Aug;206(2):159-169. Epub 2010 May 27. PDF
  • Ahn, R.W., Chen, F., Chen, H., Stern, S.T., Clogston, J.D., Patri, A.K., Raja, M.R., Cryns, V.L., O’Halloran, T.V. “A Novel Nanoparticulate Formulation of Arsenic Trioxide with Enhanced Therapeutic Efficacy in a Murine Model of Breast Cancer” Clin Cancer Res. 2010. Accepted for Publication May 2010. PDF
  • Bhalla, S., Gordon, LI, David, K., Prachand, S., Singh, A. T., Yang, S., Winter, JN, Guo, D., O’Halloran, T.V., Platanias, L., Evens, A. Glutathione depletion enhances arsenic trioxide-induced apoptosis in lymphoma cells through mitochondrial-independent mechanisims. Br J Haematol. 2010 In process. PDF
  • Alvarez, H.M., Xue, Y., Robinson, C.D., Canalizo-Hernández, M.A., Marvin, R.G., Kelly,R.A., Mondragón, A., Penner-Hahn, J.E., O’Halloran, T.V. Tetrathiomolybdate Inhibits Copper Trafficking Proteins Through Metal Cluster Formation. Science. 2010 Jan 327(5963):331-334. PDF

2005 – 2009

  • Chen, H., Pazicni, S., Krett, N.L., Ahn, R.W., Penner-Hahn, J.E., Rosen, S.T. and O’Halloran, T.V. Coencapsulation of Arsenic- and Platinum based Drugs for Targeted Cancer Treatment. Angew. Chem. Int. Ed. 2009 Nov 5;48(49):9295-9299. PDF
  • You EA, Ahn RW, Lee MH, Raja MR, O’Halloran T.V., Odom TW. Size Control of Arsenic Trioxide Nanocrystals Grown in Nanowells. J. Amer. Chem. Soc. 2009 131 (31):10863-5. PDF
  • Lee SM, Chen H, O’Halloran T.V., Nguyen SBT. Clickable’ Polymer-Caged Nanobins as a Modular drug Delivery Platform. J. Amer. Chem. Soc. 2009 131(26):9311-20. PDF
  • Chen H, Ahn R, Van den Bossche J, Thompson DH, O’Halloran T.V. Folate-mediated Intracellular Drug Delivery Increases the Anti-cancer Efficacy of Nanoparticulate Formulation of Arsenic Trioxide.  Molecular Cancer Therapeutics. 2009 8(7):1955-63. PDF
  • Furukawa Y, Kaneko K, Yamanaka K, O’Halloran T.V., Nukina N. Complete Loss of Post-translational Modifications Triggers Fibrillar Aggregation of SOD1 in the Familial Form of Amyotrophic Lateral Sclerosis. J Biol Chem. 2008  283(35):24167-76. PDF
  • Davis, A.V., O’Halloran, T.V. “A place for thioether chemistry in cellular copper ion recognition and trafficking.” Nature Chemical Biology, 2008, 4, 148-151. PDF
  • Chen, H., MacDonald, R.C., Li, S., Krett, N.L., Rosen, S.T., O’Halloran, T.V. “Lipid encapsulation of arsenic trioxide attenuates cytotoxicity and allows for controlled anticancer drug release.” J. Amer. Chem. Soc., 2006, 128, 13348-13349. PDF | Supplemental Information
  • Culotta, V.C., Yang, M., O’Halloran, T.V. “Activation of Superoxide Dismutases: Putting the Metal to the Pedal.” Biochim. Biophys. Acta, 2006, 1763, 747-758. PDF
  • Furukawa, Y., O’Halloran, T.V. “Posttranslational modifications in Cu,Zn-superoxide dismutase and mutations associated with amyotrophic lateral sclerosis.” Antiox. Redox. Signal., 2006, 8, 847-867. PDF
  • Deng, H.X., Shi, Y., Furukawa, Y., Zhai, H., Fu, R., Liu, E., Gorrie, G.H., Khan, M.S., Hung, W.Y., Bigio, E.H., Lukas T., Dal Canto, M.C., O’Halloran, T.V., Siddique, T. “Conversion to the amyotrophic lateral sclerosis phenotype is associated with intermolecular linked insoluble aggregates of SOD1 in mitochondria.” Proc. Natl. Acad. Sci, 2006, 103, 7142-7147. PDF
  • Furukawa, Y., Fu, R., Deng, H.X., Siddique, T., O’Halloran, T.V. “Free in PMC Disulfide cross-linked protein represents a significant fraction of ALS-associated Cu, Zn-superoxide dismutase aggregates in spinal cords of model mice.” Proc. Natl. Acad. Sci., 2006, 103, 7148-7153. PDF
  • Furukawa, Y., O’Halloran, T.V. “ALS Mutations have the Greatest Destabilizing Effect on the apo,reduced form of SOD1, Leading to unfolding and oxidative aggregation” J. Biol. Chem., 2005, 280, 17266-17274. PDF | Supplemental Information

2000 – 2004

  • Arnesano, F., Banci, L., Bertini, I., Martinelli, M., Furukawa, Y., O’Halloran, T.V. “The Unusually Stable Quaternary Structure of Human SOD1 is Controlled by Both Metal Occupancy and Disulfide Status” J. Biol. Chem. 2004, 279, 47998-48003. PDF | Supplemental Information
  • Culotta, V.C., O’Halloran, T.V. Metallochaperones, In Biological Inorganic Chemistry: Structure and Reactivity I. Bertini, H.B. Gray, E.I. Stiefel and J.S. Valentine, Eds. University Science Books, Mill Valley, CA, 2006
  • Furukawa, Y., Torres, A.S., O’Halloran, T.V. “Oxygen-induced MAturation of SOD1: A Key Role for Disulfide Formation by the Copper Chaperone CCS”, The EMBO Journal, 2004,23, 2872-2881. PDF | Supplemental Information
  • Brown, N.M., Torres, A.S., Doan, P.E., O’Halloran, T.V. “Oxygen and the Copper Chaperone CCS Regulate Post-Translational Activation of Cu,Zn Superoxide Dismutase” Proc. Natl. Acad. Sci., 2004, 101, 5518-5523. PDF
  • Taki, M., Wolford, J., O’Halloran, T.V. “Emission Ratiometric Imaging of Intracellular Zinc: Design of a Benzoxazole Fluorescent Sensor and its application in Two-Photon Microscopy” J. Amer. Chem. Soc., 2004, 126, 712-713. PDF | Supplemental Information
  • Chen, K., Yuldasheva, S., Penner-Hahn, J.E., O’Halloran, T.V. “An Atypical Linear Cu(I)-S2 Center Constitutes the High-Affinity Metal-Sensing Site in the CueR Metalloregulatory Protein” J. Amer. Chem. Soc., 2003, 125, 12088-12089. PDF | Supplemental Information
  • Changela, A., Chen, K., Xue, Y., Holschen, J., Outten, C.E., O’Halloran, T.V., Mondragon, A. “Molecular Basis of Selectivity and Zeptomolar Sensitivity by CueR” Science, 2003,301, 1383-1387. PDF | Supplemental Information
  • Finney, L.A., O’Halloran, T.V. “Transition Metal Speciation in the Cell: Insights from the Chemistry of Metal Ion Receptors” Science, 2003, 300, 931-936. PDF
  • Peariso, K., Huffman, D.L., Penner-Hahn, J.E., and O’Halloran, T.V. “The PcoC Copper Resistance Protein Coordinates Cu(I) via Novel S-Methionine Interactions” J. Amer. Chem. Soc 2003, 125, 2, 342-343. PDF
  • Wernimont, A.K., Huffman, D.L., Finney, L.A., Demeler, B., O’Halloran, T.V., Rosenzweig, A.C. “Crystal structure and dimerization equilibria of PcoC, a methionine rich copper resistance protein from Escherichia coli” J. Biol. Inorg. Chem. 2003, 8, 185-194. PDF
  • Finney, L.A., Ciofi-Baffoni, S., Outten, C.E., Banci, L., Bertini, I., and O’Halloran, T.V. “A new zinc protein coordination site in an intracellular metal-trafficking protein: Solution structure of the apo and Zn(II) forms of ZntA(46-118)” J. Mol. Biol., 2002, 323, 883-897. PDF
  • Huffman, D.L., Huyett, J., Outten, F.W., Doan, P.E., Finney, L.A., Hoffman, B.M., O’Halloran, T.V., “ENDOR Spectroscopy of Cu(II)-PcoC and the Multicopper Oxidase Function of PcoA, Two Essential Components of the pco Copper Resistance Operon in Escherichia coli” Biochemistry, 2002, 41, 31, 10046-10055. PDF
  • Arnesano, F., Banci, L., Bertini, I., Ciofi-Baffoni, S., Molteni, E., Huffman, D.L., and O’Halloran, T.V. “Metallochaperones and Metal-Transporting ATPases: A Comparative Analysis of Sequences and Structures” Genome Research, 2002, 12, 255-271. PDF
  • Torres, A., Petri, V., Rae, T., O’Halloran, T. “Copper Stabilizes a Heterodimer of the yCCS Metallochaperone and its Target Superoxide Dismutase” J. Biol. Chem., 2001, 276, 38410-38416. PDF
  • Lamb, A.L., Torres, A.S., O’Halloran, T.V., Rosenzweig, A.C., “Heterodimeric structure of superoxide dismutase in complex with its metallochaperone” Nature Structural Biology2001, 8, 751-755. PDF
  • Outten, C.E., O’Halloran, T.V., “Femtomolar Sensitivity of Metalloregulatory Proteins Controlling Zinc Homeostasis” Science 2001, 292, 2488-2492 PDF
  • Hitomi, Y., Outten, C.E., O’Halloran, T.V “Extreme Zinc-binding Thermodynamics of the Metal Sensor/Regulator protein, ZntR” J. Amer. Chem. Soc. 2001, 123, 35, 8614-8615 PDF
  • Outten, C.E., Tobin, D.A., Penner-Hahn, J.E., and O’Halloran, T.V. “Characterization of the Metal Receptor Sites in E. coli Zur, an Ultrasensitive Zn(II) Metalloregulatory Protein”Biochemistry 2001, 40, 35, 10417-10423. PDF
  • Outten, F.W., Huffman, D., Hale, J., O’Halloran, T.V., “The Independent cue and cus Systems Confer Copper Tolerance During Aerobic and Anaerobic Growth in Escherichia coli” J. Biol. Chem. 2001, 276, 30670-30677. PDF
  • Huffman, D., and O’Halloran, T. V. “Function, Structure, and Mechanism of Intracellular Copper-Trafficking Proteins” Ann. Rev. Biochemistry, 2001, 70, 677-701. PDF
  • Rae, T., Torres, A., Pufahl, R., O’Halloran, T. “Mechanism of Cu, Zn-Superoxide Dismutase Activation By the Human Metallochaperone CCS”, J. Biol. Chem. 2001, 276, 7, 5166-5176. PDF
  • Arnesano, F., Banci, L., Bertini, I., Cantini, F., Ciofi-Baffoni, S., Huffman, D., O’Halloran, T.V., “Characterization of the Binding Interface between the Copper Chaperone Atx1 and the First Cytosolic Domain of Ccc2 ATPase” J. Biol. Chem. 2001, 276, 41365-41376. PDF
  • Banci, L., Bertini, I., Simone, C., Huffman, D., O’Halloran, T. “Solution Structure of the Yeast Copper Transporter Domain Ccc2a in the apo and Cu(I) Loaded States”J. Biol. Chem.2001, 276, 8415-8426. PDF
  • Arnesano, F., Banci, L, Bertini, I., Huffman, D., and O’Halloran, T. “Solution structure of the Cu(I) and apo-forms of the Yeast Metallochaperone, Atx1” Biochemistry 2001, 40, 1528-1539. PDF
  • Lamb, A., Torres, A., O’Halloran, T. V., and Rosenzweig, A. C. “Heterodimer Formation between Superoxide Dismutase and Its Copper Chaperone” Biochemistry 2000, 39, 48, 14720-14727. PDF
  • Outten, F.W., Outten, C., Hale, J., and O’Halloran, T. “Transcriptional Activation of an E. coli Copper Efflux Regulon by the Chromosomal MerR Homologue, CueR” J. Biol. Chem..2000, 275, 31024-31029. PDF
  • Munson, G.P., Lam, D.L., Outten, F.W., and O’Halloran, T.V. “Identification of a Chromosomal Copper Responsive Regulatory Locus from Escherichia coli K12”, J. Bacteriology2000, 182, 5864-5871. PDF
  • Wernimont, A. K.; Huffman, D. L.; Lamb, A. L.; O’Halloran, T. V.; Rosenzweig, A. C. “Structural Basis for Metal Ion Transfer by the Copper Chaperone for the Menkes and Wilson Disease Protein” Nature Structural Biology 2000, 7, 9, 766-771. PDF
  • O’Halloran, T.V and Culotta V.C. “Metallochaperones: An Intracellular Shuttle Service for Metal Ions” J. Biol. Chem. 2000, 275, 33, 25057-25060. PDF
  • Huffman, D.L. and O’Halloran, T.V “Energetics of Copper Trafficking Between the Atx1 Metallochaperone and the Intracellular Copper-transporter, Ccc2” J. Biol. Chem.., 2000,275, 25, 18611-18614. PDF
  • Rosenzweig, A.C. and O’Halloran, T.V., “Structure and Chemistry of the Copper Chaperone Proteins” Current Opinion in Chem. Biol., 2000, 4, 140-147.
  • Lamb, A.L., Wernimont, A.K., Pufahl, R.A., O’Halloran, T.V. and Rosenzweig, A.C. “Crystal Structure of the Second Domain of the Human Copper Chaperone for Superoxide Dismutase” Biochemistry, 2000, 39, 1589-1595. PDF
  • Outten, F.W., Outten, C.E. and O’Halloran, T.V. “Metalloregulatory Systems at the Interface Between Bacterial Metal Homeostasis and Resistance” In Bacterial Stress Responses, Storz, G., Ed. ASM Press 2000, 145-157.

1995 – 1999

  • Outten, C.E., Outten, F.W. and O’Halloran, T.V. “DNA Distortion Mechanism for Transcriptional Activation by ZntR, a Zn(II)-responsive MerR homologue in E. coli.” J. Biol. Chem.1999, 274, 37517-37524. PDF
  • Nasir, M.S., Fahrni, C.J., Suhy, D.A., Kolodsick, K.J., Singer, C.P. and O’Halloran, T.V. “The Chemical Cell Biology of Zinc: Structure and Intracellular Fluorescence of Zinc-Quinolinesulfonamide Complex” J. Biol. Inorg. Chem. 1999, 4, 775-783. PDF
  • Fahrni, C.J. and O’Halloran, T.V. “Aqueous Coordination Chemistry of Quinoline-based Fluorescence Probes for the Biological Chemistry of Zinc” J. Amer. Chem. Soc. 1999, 121,49, 11448-11458. PDF
  • Fleissner, G., Kozlowski, P.M., Vargek, M., Bryson, J.W., O’Halloran, T.V. and Spiro, T.G. “UVRR Spectroscopy and Vibrational Analysis of Mercury Thiolate Compounds Resembling d10 Metal Binding Sites in Proteins” Inorg. Chem., 1999, 38, 3523-3528. PDF
  • Portnoy, M.E., Rosenzweig, A.C., Rae, T., Huffman, D.L., O’Halloran, T.V., and Culotta, V.C. “Sturcture-Function Analyses of the ATX1 Metallochaperone” J. Biol. Chem.. 1999,274, 15041-15045. PDF
  • Schmidt, P.J., Rae, T.D., Pufahl, R.A., Strain, J., Hamma, T., O’Halloran, T.V., Culotta, V.C. “Multiple Protein Domains Contribute to the Action of the Copper Chaperone for Superoxide Dismutase” J. Biol. Chem.., >1999, 247, 23719-23725. PDF
  • Lamb, L.L., Wernimont, A.K., Pufahl, R.A., O’Halloran, T.V., Rosenzweig, A.C. “Crystal Structure of the Copper Chaperone for Superoxide Dismutase” Nature Structural Biology,1999, 6, 724-729. PDF
  • Note: See News and Views “Helping copper find a home” by T. Poulos, p. 709-711 in the same issue.
  • Rosenzweig, A.C., Huffman, D.L., Hou, M.Y., Wernimont, A.K., Pufahl, R.P., and O’Halloran, T.V. “Crystal Structure of the Atx1 Metallochaperone Protein at 1.02 A Resolution”Structure, 1999, 7, 605-617. PDF
  • Rae, T.D., Schmidt, P.J., Pufahl, R.A., Culotta, V.C., and O’Halloran, T.V. “Undetectable Free Intracellular Copper: the Requirement of a Copper Chaperone for Superoxide Dismutase” Science, 1999, 284, 805-808.Note: See Perspective “Free Copper Ions in the Cell” by S.J. Lippard, p. 748-749 in the same issue.
  • Althaus, E.W., Outten, C.E., Olson, K.E., Cao, H., and O’Halloran, T.V. “The Ferric Uptake Regulation (Fur) Repressor Is a Zinc Metalloprotein” Biochemistry, 1999, 38, 6559-6569. PDF
  • Suhy, D.A., Simon, K.D., Linzer, D.I.H., O’Halloran, T.V. “Metallothionein is Part of a Zinc-Scavenging Mechanism for Cell Survival Under Conditions of Extreme Zinc Deprivation”J. Biol. Chem., 1999, 274, 9183-9192. PDF
  • Pufahl, R.A. and O’Halloran, T.V. “Mechanisms of Copper Chaperone Proteins”, In Metals and Genetics, B. Sarkar, Ed., New York, Plenum Publishing Corporation, 1999.
  • Valentine, J.S. and O’Halloran, T.V. “Bio-inorganic chemistry: what is it, and what’s so exciting?” Current Opinion in Chemical Biology, 1999, 3, 129-130. PDF
  • Fleissner, G., Reigle, M.D., O’Halloran, T.V. and Spiro, T.G. “UVRR Spectroscopy of the Metal Receptor Site in MerR” J. Amer. Chem. Soc., 1998, 120, 12690-12691. PDF
  • Pufahl, R.A. and C.P. Singer, K.L. Peariso, S.-J. Lin, P. Schmidt, V. Cizewski Culotta, J.E. Penner-Hahn, T.V. O’Halloran, “Metal Ion Chaperone Function of the Soluble Cu(I) Receptor, Atx1” Science, 1997, 278, 853-856. PDF
  • See Perspective “Delivering Copper Inside Yeast and Human Cells” by J.S. Valentine and E.B. Gralla, pgs. 817-818 in the same issue.
  • Dieckmann, G.R., McRorie, D.K. Tierney, D.L., Utschig, L.M., Singer, C.P. O’Halloran, T.V. Penner-Hahn, J.E., DeGrado, W.F., Pecoraro, V.L. “The De Novo Design of Mercury-Binding Two- and Three-Helical Bundles.” J. Amer. Chem. Soc., 1997, 119, 6195-6196. PDF
  • O’Halloran, T.V. and Malin, J.M. “Pentacyanoiron (III) Pyridine Derivatives as Topological Probes for Electron Transfer Cytochrome c,” Kinetics and Catalysis, 1996, 37, 676-682.
  • Utschig, L., Baynard, T., Strong, C. and O’Halloran, T.V. . “Probing the Copper Coordination Chemistry of Rusticyanin and Azurin by 2D 1H-199Hg NMR” Inorg. Chem., 1997, 36, 2926-2927. PDF
  • Pufahl, R., Dancis, A., O’Halloran, T.V., Culotta, V.C. “A Role for the Saccharomyces cerevisiae ATX1 Gene in Copper Trafficking and Iron Transport” J. Biol. Chem., 1997, 272, 9215-9220. PDF
  • Huffman, D., Utschig, L and O’Halloran, T. V. ” Mercury Responsive Gene Regulation and 199Hg as a Probe of Protein Structure.” in Metal Ions in Biological Systems, H. Sigel, ed., Marcel Dekker, NY, Vol. 34, 1997, 503-526.
  • Kaplan, J. and O’Halloran, T.V. “Iron Metabolism in Eukaryotes: Mars and Venus at It Again”, Science, 1996, 271, 1510-1512.
  • Suhy, D. and O’Halloran, T. “Metal Responsive Gene Regulation and the Zinc Metalloregulatory Model”, in Metal Ions in Biological Systems, H. Sigel, ed., Marcel Dekker, NY, Vol. 32, 1995, 557-578.
  • Fackler, N., Zhang, S. and O’Halloran, T. “Stabilization of High Valent Terminal-oxo-complexes: The Interplay of D-orbital Occupancy and Coordination Geometry”, J. Amer. Chem. Soc., 1996, 118, 481-482. PDF
  • Utschig, L., Wright, J., Dieckmann, G., Pecoraro, V. and O’Halloran, T. “The 199Hg Chemical Shift as a Probe of Coordination Environments in Blue Copper Proteins”, Inorg. Chem.,1995, 34, 2497-2498. PDF
  • Utschig, L., Bryson, J., O’Halloran, T. “Mercury-199 NMR of the Metal Receptor Site in MerR and Its Protein-DNA Complex”, Science, 1995, 268, 380-385.
  • Ansari, A.Z., Bradner, J.E., O’Halloran, T.V. “DNA Bend Modulation in a Repressor -to-Activator Switching Mechanism”. Nature, 1995, 374, 371-375. PDF
  • Han, M.; Peersen, O.B.; Bryson, J.W.; O’Halloran, T.V.; Smith, S.O. “Enhanced Cross Polarization in Magic Angle Spinning NMR of Metal Complexes”, Inorg. Chem., 1995, 34, 1187-1192. PDF

1990 – 1994

  • MacDonnell, F.; Fackler, T.; Stern, C.; O’Halloran, T.V. “Air Oxidation of Five Coordinate, Alkoxide Bridged Mn(III) Dimer to Mn(V) Oxo Complex”. J. Amer. Chem. Soc., 1994,116, 7431-7432. PDF
  • Ansari, A. Z., O’Halloran, T.V., “An Emerging Role for Allosteric Modulation of DNA Structure in Transcription” in Mechanisms and Regulation, R.C. Conaway, J.W. Conaway, eds., Raven Press, New York, 1994. p. 369-386.
  • Broderick, J.; Natan, M.J.; Van Duyne, R.P.; O’Halloran, T.V. “Evidence for Retention of Biological Activity of a Non-Heme Iron Enzyme Adsorbed on a Silver Colloid: A Surface-Enhanced Resonace Raman Scattering Study”. Biochemistry, 1993, 32, 13771-13776. PDF
  • O’Halloran, T. V. “Transition Metals in Control of Gene Expression”. Science, 1993, 261, 715-725. PDF
  • Utschig, L.; Wright, J.; O’Halloran, T.V. “Preparation and Spectroscopic Characterization of Mercury Complexes of Metalloproteins”. Methods in Enzymology: Metallobiochemistry: Part C, Vol. 226, Editors: J.F. Riordan, B.L. Vallee, New York: Academic Press, 1993 p. 71-97
  • Bryson, J.W.; O’Halloran, T.V.; Rouch, D.A.; Brown, N.L.; Camakaris, J.; Lee, B.T.O.; “Chemical and Genetic Studies of Copper Resistance in E. coli”. Bioinorganic Chemistry of Copper, K. D. Karlin and Z. Tyeklar, eds., Chapman & Hall, NewYork, 1993, p. 101-109.
  • Parkhill, J.; Ansari, A.Z.; Wright, J.G.; Brown, N.L.; O’Halloran, T.V.; “Construction and Characterization of a Mercury-Independent MerR Activator (MerRAC): Transcriptional Activation in the Absence of Hg(II) is Accompanied by DNA Distortion”, European Molecular Biology Organization (EMBO) Journal, 1993, 12, 413-421. PDF
  • Clark, K.; Utschig, L.; O’Halloran, T.V.; Penner-Hahn, J.E. “Structural Characterization of the Binding Site in the MerR Metalloregulatory Protein”, Jpn. J. Appl. Phys., 1993, 32, 536-537. PDF
  • Ansari, A.Z., Chael, M.L., O’Halloran, T.V. “Allosteric Underwinding of DNA is a Critical Step in Positive Control of Transcription by MerR”, Nature,1992,355, 87-89.PDF
  • Kirtley, S.M., Mullins, O.C., Chen, J., Elp, J.V., George, S.J., Chen, C.T., O’Halloran, T.V., Cramer, S.P. “Nitrogen Chemical Structure in DNA and Related Molecules by X-ray Absorption Spectroscopy”, Biochim. Biophys. Acta, 1992, 1132, 3, 249-254.Abstract
  • Broderick, J.B., O’Halloran, T.V., “Overproduction, Purification, and Characterization of a Chlorocatechol Dioxygenase, a Non-Heme Iron Dioxygenase with Broad Substrate Tolerance”, Biochemistry, 1991, 30, 7349-7358.
  • Frantz, B., O’Halloran, T.V., “DNA Distortion Accompanies Transcriptional Activation by a Metal-Responsive Gene-Regulatory Protein MerR”, Biochemistry, 1990, 29, 4747-4751.
  • Ralston, D.M. and O’Halloran, T.V. “Ultrasensitivity and heavy-metal selectivity of the allosterically modulated MerR transciption complex”, Proceedings of the National Academy of Science, 1990, 87, 3846-3850.
  • Ralston, D.M., O’Halloran, T.V., “Metalloregulatory Proteins and Molecular Mechanisms of Heavy Metal Signal Transduction”, in Advances in Inorganic Biochemistry, G. Eichhorn, L. Marzilli eds. Elsevier, New York 1990, 1-32.
  • Watton, S.P., Wright, J.G., MacDonnell, F.M., Bryson, J.W., Sabat, M., O’Halloran, T.V., “Trigonal Mercuric Complex of an Aliphatic Thiolate: A Spectroscopic and Structural Model for the Receptor Site in the Hg(II) Biosensor MerR”, J. Amer. Chem. Soc., 1990, 112, 2824-2826.
  • Natan, M.J., Millikan, C.F., Wright, J.G., O’Halloran, T.V., “Solid-State 199Hg Nuclear Magnetic Resonance as a Probe of Coordination Number and Geometry in Hg(II) Complexes”, J. Amer. Chem. Soc., 1990, 112, 3255-3257.
  • Wright, J.G., Tsang, H-T, Penner-Hahn, J.E., O’Halloran, T.V., “Coordination Chemistry of the Hg-MerR Metalloregulatory Protein: Evidence for a Novel Tridentate Hg-Cysteine Receptor Site”, J. Amer. Chem. Soc., 1990, 112, 2434-2435.
  • Wright, J.W., Natan, M.J., MacDonnell, F.M., Ralston, D.M., O’Halloran, T.V., “Mercury(II) Thiolate Chemistry and the Mechanism of the Heavy Metal Biosensor MerR”, inProgress in Inorganic Chemistry, S.J. Lippard, ed. John Wiley & Sons, New York, 1990, 38, 323-412.

1978 – 1990

  • Frantz, B.; O’Halloran, T.V., “Inorganic Reagents as Probes for the Mechanism of a Metal-Responsive Genetic Switch”, in Transition-Metal Nucleic Acid Chemistry, T. Tullius, ed. ACS Books: Washington, DC, 1989, pp. 97-105.
  • O’Halloran, T.V.; Frantz, B.; Shin, M.K.; Ralston, D.M.; Wright, J.G., “The MerR Heavy Metal Receptor Mediates Positive Activation in a Topologically Novel Transcription Complex” Cell, 1989, 56, 119-129.
  • O’Halloran, T.V., “Metalloregulatory Proteins: Metal Responsive Molecular Switches Governing Gene Expression”, in Metal Ions in Biological Systems, H. Sigel, ed., Marcel Dekker, NY, Vol. 25, 1989 pp. 105-146.
  • Ralston, D.; Frantz, B.; Shin, J.; Wright, J.; O’Halloran, T.V., “In Vitro Analysis of the MerR Metalloregulatroy Protein: A Heavy Metal-Responsive Regulator of Gene Expression”, in Metal Ion Homeostasis: Molecular Biology and Chemistry; UCLA Symposium on Molecular and Cellular Biology , New Series Vol. 98, D. Winge and D. Hamer eds., Alan Liss, Inc. New York, New York, 1989, 407-416.
  • O’Halloran, T.V.; Lippard, S.J., “Isomerization of Binuclear Amidate- Bridged Platinum(II) Amine Complexes — A 195Pt NMR Investigation”, Inorg. Chem., 1989, 27, 1289-1295.
  • O’Halloran, T.V.; Walsh, C.T., “Metalloregulatory DNA-Binding Protein Encoded by MerR Gene: Isolation and Characterization.” Science, 1987, 235, 211-214.
  • O’Halloran, T.V.; Lippard, S.J.; Richmond, T.J.; Klug, A., “Multi Heavy-atom Reagents for Macromolecular X-ray Structure Determination: Application to the Nucleosome Core Particle.” J. Mol. Biol., 1987, 194, 705-712.
  • O’Halloran, T.V.; Mascharak, P.K.; Williams, I.D.; Roberts, M.M.; Lippard, S.J., “Synthesis, Structure Determination, and Electronic Structure Characterization of Two Mixed-Valence Tetranuclear Platinum Blues with Bridging a-Pyridonate or 1-Methyluracilate Ligands.” Inorg. Chem., 1987, 26, 1261-1270.
  • O’Halloran, T.V.; Roberts, M.M.; Lippard, S.J., “Synthesis, Structure, and 195Pt NMR Solution Studies of a Reactive Binuclear Platinum(III) Complex: [Pt2(en)2(C5H4NO)2(NO2)(NO3)](NO3)2.0.5 H2O.” Inorg. Chem., 1986, 25, 957-964.
  • O’Halloran, T.V.; “Structural, Theoretical, and 195Pt NMR Solution Studies of the Platinum Blues and Related Clusters Containing Platinum in the +2 and +3 Oxidation States.”Doctoral Thesis, Columbia University, New York, 1985, 1-273.
  • O’Halloran, T.V.; Lippard, S.J., “The Chemistry of Platinum in the +3 Oxidation State.” Isrl. J. Chem., 1985, 25, 130-137.
  • O’Halloran, T.V.; Roberts, M.M.; Lippard, S.J., “Correlation between Metal-Metal Distances and Optical Spectrosco py in the Platinum Blues: Synthesis, Crystal Structure, and Electronic Spectrum of Ethylenediamineplatinum a-Pyridone Blue.” J. Amer. Chem. Soc., 1984, 106, 6427-6428.
  • Ginsberg, A.P.; O’Halloran, T.V.; Fanwick, P.E.; Hollis, L.S.; Lippard, S.J., “Electronic Structure and Optical Spectrum of cis-Diammineplatinum a-Pyridone Blue: Metal-Metal Bonding and Charge Transfer in a Four-Atom Pt(2.25) Chain”, J. Amer. Chem. Soc., 1984, 106, 5430-5439.
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